Physiological roles of Regulated Ire1 Dependent Decay
Ire1 is an important transducer of the Unfolded Protein Response (UPR) that is activated by the accumulation of misfolded proteins in the Endoplamic Reticulum (ER stress). Activated Ire1 mediates the splicing of an intron from the mRNA of Xbp1, causing a frame-shift during translation and introducin...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2014-04-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00076/full |