Transcriptomic signatures associated with autoimmune thyroiditis in papillary thyroid carcinoma and cancer immunotherapy-induced thyroid dysfunction

Transcriptomic signatures associated with autoimmune thyroiditis in papillary thyroid carcinoma and cancer immunotherapy-induced thyroid dysfunction

Up to 20% of patients treated with anti-PD-1/PD-L1 inhibitors suffered from thyroid dysfunctions, yet the mediators associated with their occurrence remain unclear. The increasing coincidence of papillary thyroid carcinoma (PTC) with Hashimoto thyroiditis (HT) and the high vulnerability of thyroid t...

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Bibliographic Details
Main Authors: Yi Li, Yue Zang, Tianda Fan, Zhaochen Li, Anzi Li, Wei Lv, Qingqing Wang, Qinglan Li, Yuanyuan Li, Quan Li, Zhongsheng Sun, Huajing Teng
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Computational and Structural Biotechnology Journal
Subjects:
Transcriptomic landscape
Immune checkpoint inhibitors
Immune-related adverse events
Thyroid dysfunction
Autoimmune thyroiditis
Papillary thyroid cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2001037022001751

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http://www.sciencedirect.com/science/article/pii/S2001037022001751

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