Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest

Brain Kynurenine Pathway and Functional Outcome of Rats Resuscitated From Cardiac Arrest

Background Brain injury and neurological deficit are consequences of cardiac arrest (CA), leading to high morbidity and mortality. Peripheral activation of the kynurenine pathway (KP), the main catabolic route of tryptophan metabolized at first into kynurenine, predicts poor neurological outcome in...

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Bibliographic Details
Main Authors: Jacopo Lucchetti, Francesca Fumagalli, Davide Olivari, Roberta Affatato, Claudia Fracasso, Daria De Giorgio, Carlo Perego, Francesca Motta, Alice Passoni, Lidia Staszewsky, Deborah Novelli, Aurora Magliocca, Silvio Garattini, Roberto Latini, Giuseppe Ristagno, Marco Gobbi
Format: Article
Language:English
Published: Wiley 2021-12-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
cardiac arrest
cardiopulmonary resuscitation
indoleamine 2,3‐deoxygenase
kynurenine pathway
neurological deficit
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.121.021071

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https://www.ahajournals.org/doi/10.1161/JAHA.121.021071

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