Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

Microglial senescence contributes to female-biased neuroinflammation in the aging mouse hippocampus: implications for Alzheimer’s disease

Abstract Background Microglia, the brain’s principal immune cells, have been implicated in the pathogenesis of Alzheimer’s disease (AD), a condition shown to affect more females than males. Although sex differences in microglial function and transcriptomic programming have been described across deve...

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Bibliographic Details
Main Authors: Sarah R. Ocañas, Kevin D. Pham, Jillian E. J. Cox, Alex W. Keck, Sunghwan Ko, Felix A. Ampadu, Hunter L. Porter, Victor A. Ansere, Adam Kulpa, Collyn M. Kellogg, Adeline H. Machalinski, Manu A. Thomas, Zsabre Wright, Ana J. Chucair-Elliott, Willard M. Freeman
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Sex effects
Sex divergence
Senescence
Neuroinflammation
Hippocampus
Online Access:https://doi.org/10.1186/s12974-023-02870-2

Internet

https://doi.org/10.1186/s12974-023-02870-2

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