Genetically Engineered Triple <i>MAPT</i>-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics

Genetically Engineered Triple <i>MAPT</i>-Mutant Human-Induced Pluripotent Stem Cells (N279K, P301L, and E10+16 Mutations) Exhibit Impairments in Mitochondrial Bioenergetics and Dynamics

Pathological abnormalities in the tau protein give rise to a variety of neurodegenerative diseases, conjointly termed tauopathies. Several tau mutations have been identified in the tau-encoding gene <i>MAPT</i>, affecting either the physical properties of tau or resulting in altered tau...

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Bibliographic Details
Main Authors: Leonora Szabo, Amandine Grimm, Juan Antonio García-León, Catherine M. Verfaillie, Anne Eckert
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cells
Subjects:
tau protein
induced pluripotent stem cells
mitochondria
bioenergetics
oxidative stress
dynamics
Online Access:https://www.mdpi.com/2073-4409/12/10/1385

Internet

https://www.mdpi.com/2073-4409/12/10/1385

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