The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma

The signaling function of IDO1 incites the malignant progression of mouse B16 melanoma

Indoleamine 2,3 dioxygenase 1 (IDO1), a leader tryptophan-degrading enzyme, represents a recognized immune checkpoint molecule. In neoplasia, IDO1 is often highly expressed in dendritic cells infiltrating the tumor and/or in tumor cells themselves, particularly in human melanoma. In dendritic cells,...

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Bibliographic Details
Main Authors: E Orecchini, ML Belladonna, MT Pallotta, C Volpi, L Zizi, E Panfili, M Gargaro, F Fallarino, S Rossini, C Suvieri, A Macchiarulo, S Bicciato, G Mondanelli, C Orabona
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:OncoImmunology
Subjects:
Indoleamine 2
3-dioxygenase 1 (IDO1)
immune checkpoint
immunoreceptor Tyrosine-based inhibitory motif (ITIM)
IDO1 signaling function
B16 melanoma
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2023.2170095

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https://www.tandfonline.com/doi/10.1080/2162402X.2023.2170095

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