Fixed-parameter tractable sampling for RNA design with multiple target structures

Fixed-parameter tractable sampling for RNA design with multiple target structures

Abstract Background The design of multi-stable RNA molecules has important applications in biology, medicine, and biotechnology. Synthetic design approaches profit strongly from effective in-silico methods, which substantially reduce the need for costly wet-lab experiments. Results We devise a novel...

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Bibliographic Details
Main Authors: Stefan Hammer, Wei Wang, Sebastian Will, Yann Ponty
Format: Article
Language:English
Published: BMC 2019-04-01
Series:BMC Bioinformatics
Subjects:
RNA multi-target design
RNA secondary structure
Multi-dimensional Boltzmann sampling
# P-hardness of RNA design
Online Access:http://link.springer.com/article/10.1186/s12859-019-2784-7

Internet

http://link.springer.com/article/10.1186/s12859-019-2784-7

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