DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

DOT1L O-GlcNAcylation promotes its protein stability and MLL-fusion leukemia cell proliferation

Summary: Histone lysine methylation functions at the interface of the extracellular environment and intracellular gene expression. DOT1L is a versatile histone H3K79 methyltransferase with a prominent role in MLL-fusion leukemia, yet little is known about how DOT1L responds to extracellular stimuli....

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Bibliographic Details
Main Authors: Tanjing Song, Qingli Zou, Yingying Yan, Suli Lv, Neng Li, Xuefeng Zhao, Xianyun Ma, Haigang Liu, Borui Tang, Lidong Sun
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Cell Reports
Subjects:
O-GlcNAcylation
DOT1L
histone
methylation
glucose
MLL
Online Access:http://www.sciencedirect.com/science/article/pii/S221112472101192X

Internet

http://www.sciencedirect.com/science/article/pii/S221112472101192X

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