Endogenous PTEN acts as the key determinant for mTOR inhibitor sensitivity by inducing the stress-sensitized PTEN-mediated death axis in KSHV-associated malignant cells

Endogenous PTEN acts as the key determinant for mTOR inhibitor sensitivity by inducing the stress-sensitized PTEN-mediated death axis in KSHV-associated malignant cells

As a part of viral cancer evolution, KSHV-infected human endothelial cells exert a unique transcriptional program via upregulated mTORC1 signaling. This event makes them sensitive to mTOR inhibitors. Master transcriptional regulator PTEN acts as the prime regulator of mTOR and determining factor for...

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Bibliographic Details
Main Authors: Piyanki Das, Sonali Pal, Nilanjana Das, Koushik Chakraborty, Koustav Chatterjee, Sudipa Mal, Tathagata Choudhuri
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Molecular Biosciences
Subjects:
PTEN
mTOR inhibitors
drug sensitivity determinant
KSHV-associated malignancy
stress
PTEN-mediated cell death
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1062462/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2023.1062462/full

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