Disruption of O-GlcNAc cycling in C. elegans perturbs Nucleotide Sugar pools and Complex Glycans

Disruption of O-GlcNAc cycling in C. elegans perturbs Nucleotide Sugar pools and Complex Glycans

The carbohydrate modification of serine and threonine residues with O-linked beta-N-acetylglucosamine (O-GlcNAc) is ubiquitous and governs cellular processes ranging from cell signaling to apoptosis. The O-GlcNAc modification along with other carbohydrate modifications, including N-linked and O-lin...

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Bibliographic Details
Main Authors: Salil K Ghosh, Michelle R. Bond, Dona C. Love, G. Gilbert Ashwell, Michael W. Krause, John A. Hanover
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-11-01
Series:Frontiers in Endocrinology
Subjects:
Glycogen
Hexosamines
Trehalose
O-GlcNAcylation
nucleotide sugars
C. elegans/nematode
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00197/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2014.00197/full

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