Ranking the contribution of behavioral measures comprising oxycodone self-administration to reinstatement of drug-seeking in male and female rats

Ranking the contribution of behavioral measures comprising oxycodone self-administration to reinstatement of drug-seeking in male and female rats

IntroductionRates of relapse to drug use during abstinence are among the highest for opioid use disorder (OUD). In preclinical studies, reinstatement to drug-seeking has been extensively studied as a model of relapse–but the work has been primarily in males. We asked whether biological sex contribut...

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Bibliographic Details
Main Authors: Suman K. Guha, Yanaira Alonso-Caraballo, Gillian S. Driscoll, Jessica A. Babb, Megan Neal, Nicholas J. Constantino, Tania Lintz, Elizabeth Kinard, Elena H. Chartoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
escalation
front-loading
female
vulnerability
opioid
relapse
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1035350/full

Internet

https://www.frontiersin.org/articles/10.3389/fnbeh.2022.1035350/full

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