Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease

Cyclic multiplex fluorescent immunohistochemistry and machine learning reveal distinct states of astrocytes and microglia in normal aging and Alzheimer’s disease

Abstract Background Astrocytes and microglia react to Aβ plaques, neurofibrillary tangles, and neurodegeneration in the Alzheimer’s disease (AD) brain. Single-nuclei and single-cell RNA-seq have revealed multiple states or subpopulations of these glial cells but lack spatial information. We have dev...

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Bibliographic Details
Main Authors: Clara Muñoz-Castro, Ayush Noori, Colin G. Magdamo, Zhaozhi Li, Jordan D. Marks, Matthew P. Frosch, Sudeshna Das, Bradley T. Hyman, Alberto Serrano-Pozo
Format: Article
Language:English
Published: BMC 2022-02-01
Series:Journal of Neuroinflammation
Subjects:
Alzheimer’s disease
Amyloid plaques
Astrocytes
Immunohistochemistry
Microglia
Neurofibrillary tangles
Online Access:https://doi.org/10.1186/s12974-022-02383-4

Internet

https://doi.org/10.1186/s12974-022-02383-4

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