Downregulation of Cyclophilin A by siRNA diminishes non-small cell lung cancer cell growth and metastasis via the regulation of matrix metallopeptidase 9

Downregulation of Cyclophilin A by siRNA diminishes non-small cell lung cancer cell growth and metastasis via the regulation of matrix metallopeptidase 9

<p>Abstract</p> <p>Background</p> <p>Cyclophilin A (CypA) is a cytosolic protein possessing peptidyl-prolyl isomerase activity that was recently reported to be overexpressed in several cancers. Here, we explored the biology and molecular mechanism of CypA in non-small c...

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Bibliographic Details
Main Authors: Qian Zhe, Zhao Xiaoting, Jiang Mei, Jia Wenyun, Zhang Chunyan, Wang Yue, Li Baolan, Yue Wentao
Format: Article
Language:English
Published: BMC 2012-10-01
Series:BMC Cancer
Subjects:
Cyclophilin A
Non-small cell lung cancer
Proliferation
Metastasis
Matrix metallopeptidase 9
Online Access:http://www.biomedcentral.com/1471-2407/12/442

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http://www.biomedcentral.com/1471-2407/12/442

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