Enhanced Spike-specific, but attenuated Nucleocapsid-specific T cell responses upon SARS-CoV-2 breakthrough versus non-breakthrough infections

Enhanced Spike-specific, but attenuated Nucleocapsid-specific T cell responses upon SARS-CoV-2 breakthrough versus non-breakthrough infections

SARS-CoV-2 vaccine breakthrough infections frequently occurred even before the emergence of Omicron variants. Yet, relatively little is known about the impact of vaccination on SARS-CoV-2-specific T cell and antibody response dynamics upon breakthrough infection. We have therefore studied the dynami...

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Bibliographic Details
Main Authors: Mohamed Ibraheem Mahmoud Ahmed, Paulina Diepers, Christian Janke, Michael Plank, Tabea M. Eser, Raquel Rubio-Acero, Anna Fuchs, Olga Baranov, Noemi Castelletti, Inge Kroidl, Laura Olbrich, Bernadette Bauer, Danni Wang, Martina Prelog, Johannes G. Liese, Christina Reinkemeyer, Michael Hoelscher, Philipp Steininger, Klaus Überla, Andreas Wieser, Christof Geldmacher
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-12-01
Series:Frontiers in Immunology
Subjects:
COVID-19
adaptive immunity
vaccine
SARS Cov 2
breakthrough infection
T cell response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.1026473/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2022.1026473/full

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