Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca<sup>2+</sup>, cAMP and ACh

Taste Receptor Activation in Tracheal Brush Cells by Denatonium Modulates ENaC Channels via Ca<sup>2+</sup>, cAMP and ACh

Mucociliary clearance is a primary defence mechanism of the airways consisting of two components, ciliary beating and transepithelial ion transport (I<sub>SC</sub>). Specialised chemosensory cholinergic epithelial cells, named brush cells (BC), are involved in regulating various physiolo...

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Bibliographic Details
Main Authors: Monika I. Hollenhorst, Praveen Kumar, Maxim Zimmer, Alaa Salah, Stephan Maxeiner, Mohamed Ibrahem Elhawy, Saskia B. Evers, Veit Flockerzi, Thomas Gudermann, Vladimir Chubanov, Ulrich Boehm, Gabriela Krasteva-Christ
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Cells
Subjects:
ion transport
airway epithelium
Ussing chamber
mucociliary clearance
brush cell
ENaC
Online Access:https://www.mdpi.com/2073-4409/11/15/2411

Internet

https://www.mdpi.com/2073-4409/11/15/2411

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