Chemical Manipulation of the Endosome Trafficking Machinery: Implications for Oligonucleotide Delivery
Antisense oligonucleotides (ASOs), siRNA and splice switching oligonucleotides (SSOs) all have immense potential as therapeutic agents, potential that is now being validated as oligonucleotides enter the clinic. However, progress in oligonucleotide-based therapeutics has been limited by the difficul...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-05-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/9/5/512 |