Distinct and targetable role of calcium-sensing receptor in leukaemia

Distinct and targetable role of calcium-sensing receptor in leukaemia

Abstract Haematopoietic stem cells (HSC) reside in the bone marrow microenvironment (BMM), where they respond to extracellular calcium [eCa2+] via the G-protein coupled calcium-sensing receptor (CaSR). Here we show that a calcium gradient exists in this BMM, and that [eCa2+] and response to [eCa2+]...

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Bibliographic Details
Main Authors: Raquel S. Pereira, Rahul Kumar, Alessia Cais, Lara Paulini, Alisa Kahler, Jimena Bravo, Valentina R. Minciacchi, Theresa Krack, Eric Kowarz, Costanza Zanetti, Parimala Sonika Godavarthy, Fabian Hoeller, Pablo Llavona, Tabea Stark, Georg Tascher, Daniel Nowak, Eshwar Meduri, Brian J. P. Huntly, Christian Münch, Francesco Pampaloni, Rolf Marschalek, Daniela S. Krause
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41770-0

Internet

https://doi.org/10.1038/s41467-023-41770-0

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