Targeted therapy for LIMD1-deficient non-small cell lung cancer subtypes
Abstract An early event in lung oncogenesis is loss of the tumour suppressor gene LIMD1 (LIM domains containing 1); this encodes a scaffold protein, which suppresses tumorigenesis via a number of different mechanisms. Approximately 45% of non-small cell lung cancers (NSCLC) are deficient in LIMD1, y...
Main Authors: | , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-11-01
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Series: | Cell Death and Disease |
Online Access: | https://doi.org/10.1038/s41419-021-04355-7 |