A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease

A BET Protein Inhibitor Targeting Mononuclear Myeloid Cells Affects Specific Inflammatory Mediators and Pathways in Crohn’s Disease

<span style="text-decoration: underline;">Background</span>: Myeloid cells are critical determinants of the sustained inflammation in Crohn’s Disease (CD). Targeting such cells may be an effective therapeutic approach for refractory CD patients. Bromodomain and extra-terminal d...

Full description

Bibliographic Details
Main Authors: Ahmed M. I. Elfiky, Ishtu L. Hageman, Marte A. J. Becker, Jan Verhoeff, Andrew Y. F. Li Yim, Vincent W. Joustra, Lieven Mulders, Ivan Fung, Inmaculada Rioja, Rab K. Prinjha, Nicholas N. Smithers, Rebecca C. Furze, Palwinder K. Mander, Matthew J. Bell, Christianne J. Buskens, Geert R. D’Haens, Manon E. Wildenberg, Wouter J. de Jonge
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
BET inhibitor
CES1
IBD
Online Access:https://www.mdpi.com/2073-4409/11/18/2846

Internet

https://www.mdpi.com/2073-4409/11/18/2846

Similar Items