Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells

Differential Effects of Histone Acetyltransferase GCN5 or PCAF Knockdown on Urothelial Carcinoma Cells

Disturbances in histone acetyltransferases (HATs) are common in cancers. In urothelial carcinoma (UC), p300 and CBP are often mutated, whereas the GNAT family HATs GCN5 and PCAF (General Control Nonderepressible 5, p300/CBP-Associated Factor) are often upregulated. Here, we explored the effects of s...

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Bibliographic Details
Main Authors: Evangelia A. Koutsogiannouli, Nicholas Wagner, Christiane Hader, Maria Pinkerneil, Michèle J. Hoffmann, Wolfgang A. Schulz
Format: Article
Language:English
Published: MDPI AG 2017-07-01
Series:International Journal of Molecular Sciences
Subjects:
histone acetyltransferases
urothelial carcinoma
bladder cancer
GCN5
PCAF
p300
CBP
MDM2
c-MYC
epigenetic drugs
Online Access:https://www.mdpi.com/1422-0067/18/7/1449

Internet

https://www.mdpi.com/1422-0067/18/7/1449

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