HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model

HDAC4 represses ER stress induced chondrocyte apoptosis by inhibiting ATF4 and attenuates cartilage degeneration in an osteoarthritis rat model

Abstract Background The present study evaluated whether the lack of histone deacetylase 4 (HDAC4) increases endoplasmic reticulum stress-induced chondrocyte apoptosis by releasing activating transcription factor 4 (ATF4) in human osteoarthritis (OA) cartilage degeneration. Methods Articular cartilag...

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Bibliographic Details
Main Authors: Xiaodong Gu, Fei Li, Xianda Che, Xiaochun Wei, Pengcui Li
Format: Article
Language:English
Published: BMC 2024-06-01
Series:BMC Musculoskeletal Disorders
Subjects:
Histone deacetylase 4
Activating transcription factor 4
Endoplasmic reticulum stress
Chondrocyte apoptosis
Osteoarthritis
Online Access:https://doi.org/10.1186/s12891-024-07578-9

Internet

https://doi.org/10.1186/s12891-024-07578-9

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