Targeted Next-Generation Sequencing Indicates a Frequent Oligogenic Involvement in Primary Ovarian Insufficiency Onset

Targeted Next-Generation Sequencing Indicates a Frequent Oligogenic Involvement in Primary Ovarian Insufficiency Onset

Primary ovarian insufficiency (POI) is one of the major causes of female infertility associated with the premature loss of ovarian function in about 3.7% of women before the age of 40. This disorder is highly heterogeneous and can manifest with a wide range of clinical phenotypes, ranging from ovari...

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Bibliographic Details
Main Authors: Raffaella Rossetti, Silvia Moleri, Fabiana Guizzardi, Davide Gentilini, Laura Libera, Anna Marozzi, Costanzo Moretti, Francesco Brancati, Marco Bonomi, Luca Persani
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Endocrinology
Subjects:
primary ovarian insufficiency
primary amenorrhea
secondary amenorrhea
oligogenic disease
next-generation sequencing
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2021.664645/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2021.664645/full

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