MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA.

MicroRNA-122 triggers mesenchymal-epithelial transition and suppresses hepatocellular carcinoma cell motility and invasion by targeting RhoA.

The loss of microRNA-122 (miR-122) expression is strongly associated with increased invasion and metastasis, and poor prognosis of hepatocellular carcinoma (HCC), however, the underlying mechanisms remain poorly understood. In the present study, we observed that miR-122 over-expression in HCC cell l...

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Bibliographic Details
Main Authors: Sheng-Chun Wang, Xiao-Lin Lin, Jing Li, Ting-Ting Zhang, Hui-Yan Wang, Jun-Wen Shi, Sheng Yang, Wen-Tao Zhao, Rao-Ying Xie, Fang Wei, Yu-Juan Qin, Lin Chen, Jie Yang, Kai-Tai Yao, Dong Xiao
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4081555?pdf=render

Internet

http://europepmc.org/articles/PMC4081555?pdf=render

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