Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients

Aberrant epigenome in iPSC‐derived dopaminergic neurons from Parkinson's disease patients

Abstract The epigenomic landscape of Parkinson's disease (PD) remains unknown. We performed a genomewide DNA methylation and a transcriptome studies in induced pluripotent stem cell (iPSC)‐derived dopaminergic neurons (DAn) generated by cell reprogramming of somatic skin cells from patients wit...

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Bibliographic Details
Main Authors: Rubén Fernández‐Santiago, Iria Carballo‐Carbajal, Giancarlo Castellano, Roger Torrent, Yvonne Richaud, Adriana Sánchez‐Danés, Roser Vilarrasa‐Blasi, Alex Sánchez‐Pla, José Luis Mosquera, Jordi Soriano, José López‐Barneo, Josep M Canals, Jordi Alberch, Ángel Raya, Miquel Vila, Antonella Consiglio, José I Martín‐Subero, Mario Ezquerra, Eduardo Tolosa
Format: Article
Language:English
Published: Springer Nature 2015-10-01
Series:EMBO Molecular Medicine
Subjects:
DNA methylation
dopaminergic neuron
induced pluripotent stem cell
Parkinson's disease
transcription factor
Online Access:https://doi.org/10.15252/emmm.201505439

Internet

https://doi.org/10.15252/emmm.201505439

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