Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover.

Alpha8 Integrin (Itga8) Signalling Attenuates Chronic Renal Interstitial Fibrosis by Reducing Fibroblast Activation, Not by Interfering with Regulation of Cell Turnover.

The α8 integrin (Itga8) chain contributes to the regulation of cell proliferation and apoptosis in renal glomerular cells. In unilateral ureteral obstruction Itga8 is de novo expressed in the tubulointerstitium and a deficiency of Itga8 results in more severe renal fibrosis after unilateral ureteral...

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Bibliographic Details
Main Authors: Ines Marek, Till Lichtneger, Nada Cordasic, Karl F Hilgers, Gudrun Volkert, Fabian Fahlbusch, Wolfgang Rascher, Andrea Hartner, Carlos Menendez-Castro
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0150471&type=printable

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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0150471&type=printable

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