Defective thyroid hormone transport to the brain leads to astroglial alterations

Defective thyroid hormone transport to the brain leads to astroglial alterations

Allan-Herndon-Dudley syndrome (AHDS) is a rare X-linked disorder that causes severe neurological damage, for which there is no effective treatment. AHDS is due to inactivating mutations in the thyroid hormone transporter MCT8 that impair the entry of thyroid hormones into the brain, resulting in cer...

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Bibliographic Details
Main Authors: Marina Guillén-Yunta, Ángel García-Aldea, Víctor Valcárcel-Hernández, Ainara Sanz-Bógalo, Emma Muñoz-Moreno, Maria Gisele Matheus, Carmen Grijota-Martínez, Ana Montero-Pedrazuela, Ana Guadaño-Ferraz, Soledad Bárez-López
Format: Article
Language:English
Published: Elsevier 2024-10-01
Series:Neurobiology of Disease
Subjects:
Thyroid hormones
Thyroid hormone transporters
MCT8
Astroglia
MCT8 deficiency
MRI
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124002213

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http://www.sciencedirect.com/science/article/pii/S0969996124002213

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