SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility
The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′untranslated regions (3′UTRs) of target gene mRNAs represses translation, playing a leading role in gene expression control. MiRNA recognition elements (MREs) in the 3′UTRs of genes often contain single nucleotide...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2022-11-01
|
| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/22/13725 |
| _version_ | 1797465139873579008 |
|---|---|
| author | Elena Rykova Nikita Ershov Igor Damarov Tatiana Merkulova |
| author_facet | Elena Rykova Nikita Ershov Igor Damarov Tatiana Merkulova |
| author_sort | Elena Rykova |
| collection | DOAJ |
| description | The complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′untranslated regions (3′UTRs) of target gene mRNAs represses translation, playing a leading role in gene expression control. MiRNA recognition elements (MREs) in the 3′UTRs of genes often contain single nucleotide polymorphisms (SNPs), which can change the binding affinity for target miRNAs leading to dysregulated gene expression. Accumulated data suggest that these SNPs can be associated with various human pathologies (cancer, diabetes, neuropsychiatric disorders, and cardiovascular diseases) by disturbing the interaction of miRNAs with their MREs located in mRNA 3′UTRs. Numerous data show the role of SNPs in 3′UTR MREs in individual drug susceptibility and drug resistance mechanisms. In this review, we brief the data on such SNPs focusing on the most rigorously proven cases. Some SNPs belong to conventional genes from the drug-metabolizing system (in particular, the genes coding for cytochromes P450 (CYP 450), phase II enzymes (SULT1A1 and UGT1A), and ABCB3 transporter and their expression regulators (PXR and GATA4)). Other examples of SNPs are related to the genes involved in DNA repair, RNA editing, and specific drug metabolisms. We discuss the gene-by-gene studies and genome-wide approaches utilized or potentially utilizable to detect the MRE SNPs associated with individual response to drugs. |
| first_indexed | 2024-03-09T18:18:14Z |
| format | Article |
| id | doaj.art-007c4b56c8654dd5ae4e9e45fcc580f8 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T18:18:14Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-007c4b56c8654dd5ae4e9e45fcc580f82023-11-24T08:32:20ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-11-0123221372510.3390/ijms232213725SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug SusceptibilityElena Rykova0Nikita Ershov1Igor Damarov2Tatiana Merkulova3Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaInstitute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, 630090 Novosibirsk, RussiaThe complementary interaction of microRNAs (miRNAs) with their binding sites in the 3′untranslated regions (3′UTRs) of target gene mRNAs represses translation, playing a leading role in gene expression control. MiRNA recognition elements (MREs) in the 3′UTRs of genes often contain single nucleotide polymorphisms (SNPs), which can change the binding affinity for target miRNAs leading to dysregulated gene expression. Accumulated data suggest that these SNPs can be associated with various human pathologies (cancer, diabetes, neuropsychiatric disorders, and cardiovascular diseases) by disturbing the interaction of miRNAs with their MREs located in mRNA 3′UTRs. Numerous data show the role of SNPs in 3′UTR MREs in individual drug susceptibility and drug resistance mechanisms. In this review, we brief the data on such SNPs focusing on the most rigorously proven cases. Some SNPs belong to conventional genes from the drug-metabolizing system (in particular, the genes coding for cytochromes P450 (CYP 450), phase II enzymes (SULT1A1 and UGT1A), and ABCB3 transporter and their expression regulators (PXR and GATA4)). Other examples of SNPs are related to the genes involved in DNA repair, RNA editing, and specific drug metabolisms. We discuss the gene-by-gene studies and genome-wide approaches utilized or potentially utilizable to detect the MRE SNPs associated with individual response to drugs.https://www.mdpi.com/1422-0067/23/22/13725microRNA (miRNA)miRNA target sitessingle nucleotide polymorphisms (SNPs)3′untranslated regions (3′UTRs)drug responsepharmacogenes |
| spellingShingle | Elena Rykova Nikita Ershov Igor Damarov Tatiana Merkulova SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility International Journal of Molecular Sciences microRNA (miRNA) miRNA target sites single nucleotide polymorphisms (SNPs) 3′untranslated regions (3′UTRs) drug response pharmacogenes |
| title | SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility |
| title_full | SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility |
| title_fullStr | SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility |
| title_full_unstemmed | SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility |
| title_short | SNPs in 3′UTR miRNA Target Sequences Associated with Individual Drug Susceptibility |
| title_sort | snps in 3 utr mirna target sequences associated with individual drug susceptibility |
| topic | microRNA (miRNA) miRNA target sites single nucleotide polymorphisms (SNPs) 3′untranslated regions (3′UTRs) drug response pharmacogenes |
| url | https://www.mdpi.com/1422-0067/23/22/13725 |
| work_keys_str_mv | AT elenarykova snpsin3utrmirnatargetsequencesassociatedwithindividualdrugsusceptibility AT nikitaershov snpsin3utrmirnatargetsequencesassociatedwithindividualdrugsusceptibility AT igordamarov snpsin3utrmirnatargetsequencesassociatedwithindividualdrugsusceptibility AT tatianamerkulova snpsin3utrmirnatargetsequencesassociatedwithindividualdrugsusceptibility |