Efficacy and Safety of Granulocyte-Colony Stimulating Factor Therapy in Chagas Cardiomyopathy: A Phase II Double-Blind, Randomized, Placebo-Controlled Clinical Trial

Efficacy and Safety of Granulocyte-Colony Stimulating Factor Therapy in Chagas Cardiomyopathy: A Phase II Double-Blind, Randomized, Placebo-Controlled Clinical Trial

AimPrevious studies showed that granulocyte-colony stimulating factor (G-CSF) improved heart function in a mice model of Chronic Chagas Cardiomyopathy (CCC). Herein, we report the interim results of the safety and efficacy of G-CSF therapy vs. placebo in adults with Chagas cardiomyopathy.MethodsPati...

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Bibliographic Details
Main Authors: Carolina T. Macedo, Ticiana F. Larocca, Márcia Noya-Rabelo, Roque Aras, Cristiano R. B. Macedo, Moisés I. Moreira, Alessandra C. Caldas, Jorge A. Torreão, Victor M. A. Monsão, Clarissa L. M. Souza, Juliana F. Vasconcelos, Milena R. Bezerra, Daniela P. Petri, Bruno S. F. Souza, Antônio G. F. Pacheco, André Daher, Ricardo Ribeiro-dos-Santos, Milena B. P. Soares
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
G-CSF therapy
safety study
cardiac functional analysis
NYHA functional class
Chagas cardiomyopathy
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2022.864837/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2022.864837/full

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