Newly Synthesized Melphalan Analogs Induce DNA Damage and Mitotic Catastrophe in Hematological Malignant Cancer Cells

Newly Synthesized Melphalan Analogs Induce DNA Damage and Mitotic Catastrophe in Hematological Malignant Cancer Cells

Myeloablative therapy with highdoses of the cytostatic drug melphalan (MEL) in preparation for hematopoietic cell transplantation is the standard of care for multiple myeloma (MM) patients. Melphalan is a bifunctional alkylating agent that covalently binds to nucleophilic sites in the DNA and effect...

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Bibliographic Details
Main Authors: Anastazja Poczta, Piotr Krzeczyński, Maksim Ionov, Aneta Rogalska, Udo S. Gaipl, Agnieszka Marczak, Dorota Lubgan
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:International Journal of Molecular Sciences
Subjects:
blood cancer
DNA damage γH2AX
drug structure modification
melphalan
mitotic catastrophe
Online Access:https://www.mdpi.com/1422-0067/23/22/14258

Internet

https://www.mdpi.com/1422-0067/23/22/14258

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