NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence

Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.

Bibliographic Details
Main Authors: Aled J. Parry, Matthew Hoare, Dóra Bihary, Robert Hänsel-Hertsch, Stephen Smith, Kosuke Tomimatsu, Elizabeth Mannion, Amy Smith, Paula D’Santos, I. Alasdair Russell, Shankar Balasubramanian, Hiroshi Kimura, Shamith A. Samarajiwa, Masashi Narita
Format: Article
Language:English
Published: Nature Portfolio 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04283-9

Internet

https://doi.org/10.1038/s41467-018-04283-9

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