NOTCH-mediated non-cell autonomous regulation of chromatin structure during senescence
Notch can drive senescence in a cell contact dependent manner. Here the authors show that NOTCH signalling can modulate chromatin structure autonomously and non-autonomously via the JAG1-NOTCH-HMGA1 interplay during senescence.
Main Authors: | , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Portfolio
2018-05-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-018-04283-9 |