Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies

Emergence of spatio-temporal variations in chemotherapeutic drug efficacy: in-vitro and in-Silico 3D tumour spheroid studies

Abstract Background The mechanisms of action and efficacy of cisplatin and paclitaxel at cell population level are well studied and documented, however the localized spatio-temporal effects of the drugs are less well understood. We explore the emergence of spatially preferential drug efficacy result...

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Bibliographic Details
Main Authors: M. V. Sheraton, G. G. Y. Chiew, V. Melnikov, E. Y. Tan, K. Q. Luo, N. Verma, P. M. A. Sloot
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Cancer
Subjects:
Reaction-diffusion model
Pharmacokinetics
Pharmacodynamics
Mitotic spindle stabilization
Cytotoxicity
Online Access:https://doi.org/10.1186/s12885-020-07677-5

Internet

https://doi.org/10.1186/s12885-020-07677-5

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