Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway
Highlights 1. Circ-CSNK1G1 is upregulated in TNBC. 2. Circ-CSNK1G1 knockdown inhibits the proliferation, migration, invasion and glycolysis energy metabolism of TNBC cells. 3. Circ-CSNK1G1 knockdown inhibits tumor formation in vivo. 4. Circ-CSNK1G1 promotes TNBC development by regulating the miR-28-...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | Reproductive Biology and Endocrinology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12958-022-00998-z |
| _version_ | 1828238205129850880 |
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| author | Xiaochen Zan Wenfang Li Geng Wang Jie Yuan Yongbiao Ai Jun Huang Zhi Li |
| author_facet | Xiaochen Zan Wenfang Li Geng Wang Jie Yuan Yongbiao Ai Jun Huang Zhi Li |
| author_sort | Xiaochen Zan |
| collection | DOAJ |
| description | Highlights 1. Circ-CSNK1G1 is upregulated in TNBC. 2. Circ-CSNK1G1 knockdown inhibits the proliferation, migration, invasion and glycolysis energy metabolism of TNBC cells. 3. Circ-CSNK1G1 knockdown inhibits tumor formation in vivo. 4. Circ-CSNK1G1 promotes TNBC development by regulating the miR-28-5p/LDHA pathway. |
| first_indexed | 2024-04-12T20:59:50Z |
| format | Article |
| id | doaj.art-0087d7b6a6b24a86b609246e6cd1c03d |
| institution | Directory Open Access Journal |
| issn | 1477-7827 |
| language | English |
| last_indexed | 2024-04-12T20:59:50Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Reproductive Biology and Endocrinology |
| spelling | doaj.art-0087d7b6a6b24a86b609246e6cd1c03d2022-12-22T03:16:52ZengBMCReproductive Biology and Endocrinology1477-78272022-09-0120111410.1186/s12958-022-00998-zCirc-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathwayXiaochen Zan0Wenfang Li1Geng Wang2Jie Yuan3Yongbiao Ai4Jun Huang5Zhi Li6Department of General Surgery, Taihe Hospital, Huibei University of MedicineDepartment of General Surgery, Taihe Hospital, Huibei University of MedicineDepartment of General Surgery, Taihe Hospital, Huibei University of MedicineDepartment of General Surgery, Taihe Hospital, Huibei University of MedicineDepartment of General Surgery, Taihe Hospital, Huibei University of MedicineDepartment of General Surgery, Taihe Hospital, Huibei University of MedicineDepartment of General Surgery, Taihe Hospital, Huibei University of MedicineHighlights 1. Circ-CSNK1G1 is upregulated in TNBC. 2. Circ-CSNK1G1 knockdown inhibits the proliferation, migration, invasion and glycolysis energy metabolism of TNBC cells. 3. Circ-CSNK1G1 knockdown inhibits tumor formation in vivo. 4. Circ-CSNK1G1 promotes TNBC development by regulating the miR-28-5p/LDHA pathway.https://doi.org/10.1186/s12958-022-00998-zcirc-CSNK1G1Triple-negative breast cancermiR-28-5pLDHA |
| spellingShingle | Xiaochen Zan Wenfang Li Geng Wang Jie Yuan Yongbiao Ai Jun Huang Zhi Li Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway Reproductive Biology and Endocrinology circ-CSNK1G1 Triple-negative breast cancer miR-28-5p LDHA |
| title | Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway |
| title_full | Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway |
| title_fullStr | Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway |
| title_full_unstemmed | Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway |
| title_short | Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway |
| title_sort | circ csnk1g1 promotes cell proliferation migration invasion and glycolysis metabolism during triple negative breast cancer progression by modulating the mir 28 5p ldha pathway |
| topic | circ-CSNK1G1 Triple-negative breast cancer miR-28-5p LDHA |
| url | https://doi.org/10.1186/s12958-022-00998-z |
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