Design of orthogonal genetic switches based on a crosstalk map of σs, anti‐σs, and promoters

Design of orthogonal genetic switches based on a crosstalk map of σs, anti‐σs, and promoters

Abstract Cells react to their environment through gene regulatory networks. Network integrity requires minimization of undesired crosstalk between their biomolecules. Similar constraints also limit the use of regulators when building synthetic circuits for engineering applications. Here, we mapped t...

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Bibliographic Details
Main Authors: Virgil A Rhodius, Thomas H Segall‐Shapiro, Brian D Sharon, Amar Ghodasara, Ekaterina Orlova, Hannah Tabakh, David H Burkhardt, Kevin Clancy, Todd C Peterson, Carol A Gross, Christopher A Voigt
Format: Article
Language:English
Published: Springer Nature 2013-10-01
Series:Molecular Systems Biology
Subjects:
compiler
genetic circuit
part mining
synthetic biology
systems biology
Online Access:https://doi.org/10.1038/msb.2013.58

Internet

https://doi.org/10.1038/msb.2013.58

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