DNAM-1 chimeric receptor-engineered NK cells: a new frontier for CAR-NK cell-based immunotherapy

DNAM-1 chimeric receptor-engineered NK cells: a new frontier for CAR-NK cell-based immunotherapy

DNAM-1 is a major NK cell activating receptor and, together with NKG2D and NCRs, by binding specific ligands, strongly contributes to mediating the killing of tumor or virus-infected cells. DNAM-1 specifically recognizes PVR and Nectin-2 ligands that are expressed on some virus-infected cells and on...

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Bibliographic Details
Main Authors: Loredana Cifaldi, Ombretta Melaiu, Roberto Giovannoni, Monica Benvenuto, Chiara Focaccetti, Daniela Nardozi, Giovanni Barillari, Roberto Bei
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
CAR-NK cells
solid tumors
DNAM-1
NK cell-based immunotherapy
NK cell engineering
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197053/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1197053/full

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