Modelling the effect of subcellular mutations on the migration of cells in the colorectal crypt

Abstract Background Many cancers arise from mutations in cells within epithelial tissues. Mutations manifesting at the subcellular level influence the structure and function of the tissue resulting in cancer. Previous work has proposed how cell level properties can lead to mutant cell invasion, but...

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Main Authors: Lotte B. Romijn, Axel A. Almet, Chin Wee Tan, James M. Osborne
פורמט: Article
שפה:English
יצא לאור: BMC 2020-03-01
סדרה:BMC Bioinformatics
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גישה מקוונת:http://link.springer.com/article/10.1186/s12859-020-3391-3