Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

Chronic postnatal chemogenetic activation of forebrain excitatory neurons evokes persistent changes in mood behavior

Early adversity is a risk factor for the development of adult psychopathology. Common across multiple rodent models of early adversity is increased signaling via forebrain Gq-coupled neurotransmitter receptors. We addressed whether enhanced Gq-mediated signaling in forebrain excitatory neurons durin...

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Bibliographic Details
Main Authors: Sthitapranjya Pati, Kamal Saba, Sonali S Salvi, Praachi Tiwari, Pratik R Chaudhari, Vijaya Verma, Sourish Mukhopadhyay, Darshana Kapri, Shital Suryavanshi, James P Clement, Anant B Patel, Vidita A Vaidya
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-09-01
Series:eLife
Subjects:
DREADD
anxiety
despair
schizophrenia
early stress
mouse
Online Access:https://elifesciences.org/articles/56171

Internet

https://elifesciences.org/articles/56171

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