Matrix stiffness-dependent STEAP3 coordinated with PD-L2 identify tumor responding to sorafenib treatment in hepatocellular carcinoma

Matrix stiffness-dependent STEAP3 coordinated with PD-L2 identify tumor responding to sorafenib treatment in hepatocellular carcinoma

Abstract Background Ferroptosis have been implicated in tumorigenesis, tumor progression, and chemo- and immuno-therapy in cirrhotic hepatocellular carcinoma (HCC), indicating its association with matrix stiffness and clinical benefit of targeting drugs or immune checkpoint inhibitor. Here, we postu...

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Bibliographic Details
Main Authors: Shunxi Wang, Long Chen, Wanqian Liu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:Cancer Cell International
Subjects:
Matrix stiffness
Ferroptosis
Tumor immunity
Hepatocellular carcinoma
Cirrhosis
Online Access:https://doi.org/10.1186/s12935-022-02634-7

Internet

https://doi.org/10.1186/s12935-022-02634-7

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