Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1

Development of Triazoles and Triazolium Salts Based on AZT and Their Anti-Viral Activity against HIV-1

We report herein a set of 3′-azido-3′-deoxythymidine (AZT) derivatives based on triazoles and triazolium salts for HIV-1 infection. The compounds were synthesized via click chemistry with Cu(I) and Ru(II) catalysts. Triazolium salts were synthesized by reaction with methyl iodide or methyl triflate...

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Bibliographic Details
Main Authors: Daniel Machado de Alencar, Juliana Gonçalves, Andreia Vieira, Sofia A. Cerqueira, Cruz Sebastião, Maria Inês P. S. Leitão, Giulia Francescato, Paola Antenori, Helena Soares, Ana Petronilho
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Molecules
Subjects:
click chemistry
triazoles
triazolium salts
anti-viral
HIV-1
AZT
Online Access:https://www.mdpi.com/1420-3049/26/21/6720

Internet

https://www.mdpi.com/1420-3049/26/21/6720

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