Pro-Inflammatory Role of AQP4 in Mice Subjected to Intrastriatal Injections of the Parkinsonogenic Toxin MPP+

Aquaporin-4 (AQP4) is critically involved in brain water and volume homeostasis and has been implicated in a wide range of pathological conditions. Notably, evidence has been accrued to suggest that AQP4 plays a proinflammatory role by promoting release of astrocytic cytokines that activate microgli...

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Bibliographic Details
Main Authors: Agnete Prydz, Katja Stahl, Soulmaz Zahl, Nadia Skauli, Øivind Skare, Ole Petter Ottersen, Mahmood Amiry-Moghaddam
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/9/11/2418