Down-Regulation of Lnc-CYP7A1-1 Rejuvenates Aged Human Mesenchymal Stem Cells to Improve Their Efficacy for Heart Repair Through SYNE1

Down-Regulation of Lnc-CYP7A1-1 Rejuvenates Aged Human Mesenchymal Stem Cells to Improve Their Efficacy for Heart Repair Through SYNE1

BackgroundSeveral long non-coding RNAs (lncRNAs) have been associated with cell senescence, termed senescence-associated lncRNAs (SAL-RNAs). However, the mechanisms involved for SAL-RNAs in aging are not fully elucidated. In the present study, we investigated the effects of SAL-RNAs on aged human bo...

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Bibliographic Details
Main Authors: Jun Dong, Jianwei Liu, Yueqiang Wen, Stephanie W. Tobin, Chongyu Zhang, Huiling Zheng, Zehan Huang, Yongtao Feng, Dongcheng Zhang, Shiming Liu, Zhenhui Zhang, Jiao Li
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
aging
rejuvenation
lncRNAs
myocardial infarction
proliferation
mesenchymal stem cell
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.600304/full

Internet

https://www.frontiersin.org/articles/10.3389/fcell.2020.600304/full

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