N-acetylcysteine prevents catheter occlusion and inflammation in catheter associated-urinary tract infections by suppressing urease activity

N-acetylcysteine prevents catheter occlusion and inflammation in catheter associated-urinary tract infections by suppressing urease activity

IntroductionProteus mirabilis is a key pathobiont in catheter-associated urinary tract infections (CA-UTIs), which is well known to form crystalline biofilms that occlude catheters. Urease activity alkylates urine through the release of ammonia, consequentially resulting in higher levels of Mg2+ and...

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Bibliographic Details
Main Authors: Arthika Manoharan, Jessica Farrell, Vina R. Aldilla, Greg Whiteley, Erik Kriel, Trevor Glasbey, Naresh Kumar, Kate H. Moore, Jim Manos, Theerthankar Das
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-10-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
Proteus mirabilis
UTI
catheter-associated urinary tract infections (CA-UTI)
N-acetyl cysteine (NAC)
urease
biofilms
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2023.1216798/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2023.1216798/full

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