RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer

RNF31 represses cell progression and immune evasion via YAP/PD-L1 suppression in triple negative breast Cancer

Highlights 1. RNF31 restrains cancer cell progression in TNBC. 2. RNF31 regulates YAP protein stability via promoting YAP K48-linked poly-ubiquitination. 3. RNF31 represses immune evasion via suppressing YAP/PD-L1 axis in TNBC.

Bibliographic Details
Main Authors: Huijie Yang, Min Xue, Peng Su, Yan Zhou, Xin Li, Zhongbo Li, Yan Xia, Chenmiao Zhang, Mingxi Fu, Xiuxia Zheng, Guosheng Luo, Tian Wei, Xinxing Wang, Yinlu Ding, Jian Zhu, Ting Zhuang
Format: Article
Language:English
Published: BMC 2022-12-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
TNBC
RNF31
YAP
PD-L1
Stability
Immune evasion
Online Access:https://doi.org/10.1186/s13046-022-02576-y

Internet

https://doi.org/10.1186/s13046-022-02576-y

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