FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway

FTO-mediated demethylation of GADD45B promotes myogenesis through the activation of p38 MAPK pathway

N6-methyladenosine (m6A) modification plays a critical role in mammalian development. However, the role of m6A in the skeletal muscle development remains largely unknown. Here, we report a global m6A modification pattern of goat skeletal muscle at two key development stages and identified that the m...

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Bibliographic Details
Main Authors: Kaiping Deng, Yixuan Fan, Yaxu Liang, Yu Cai, Guomin Zhang, Mingtian Deng, Zhibo Wang, Jiawei Lu, Jianfei Shi, Feng Wang, Yanli Zhang
Format: Article
Language:English
Published: Elsevier 2021-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
m6A modification
GADD45B
FTO
myogenic differentiation
mitochondrial biogenesis
goat
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253121001542

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http://www.sciencedirect.com/science/article/pii/S2162253121001542

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