LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter

LncRNA KCNQ1OT1 promotes the metastasis of ovarian cancer by increasing the methylation of EIF2B5 promoter

Highlights 1. LncRNA KCNQ1OT1 is upregulated, while EIF2B5 is downregulated in OC tissues and cells. 2. Knockdown of KCNQ1OT1 represses OC cell proliferation and metastasis. 3. KCNQ1OT1 decreases EIF2B5 expression by recruiting DNA methyltransferases into EIF2B5 promoter, thereby promoting OC progre...

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Bibliographic Details
Main Authors: Si-Li He, Ya-Ling Chen, Qi-Hua Chen, Qi Tian, Shui-Jing Yi
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Molecular Medicine
Subjects:
Ovarian cancer
lncRNA KCNQ1OT1
EIF2B5
Methylation
Proliferation
Metastasis
Online Access:https://doi.org/10.1186/s10020-022-00521-5

Internet

https://doi.org/10.1186/s10020-022-00521-5

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