Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans

Defective regulation of the eIF2-eIF2B translational axis underlies depressive-like behavior in mice and correlates with major depressive disorder in humans

Abstract Major depressive disorder (MDD) is a significant cause of disability in adults worldwide. However, the underlying causes and mechanisms of MDD are not fully understood, and many patients are refractory to available therapeutic options. Impaired control of brain mRNA translation underlies se...

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Bibliographic Details
Main Authors: Alinny R. Isaac, Mariana G. Chauvet, Ricardo Lima-Filho, Beatriz de A. Wagner, Bruno G. Caroli, Renata E. P. Leite, Claudia K. Suemoto, Paula Villela Nunes, Fernanda G. De Felice, Sergio T. Ferreira, Mychael V. Lourenco
Format: Article
Language:English
Published: Nature Publishing Group 2024-10-01
Series:Translational Psychiatry
Online Access:https://doi.org/10.1038/s41398-024-03128-y

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https://doi.org/10.1038/s41398-024-03128-y

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