Deciphering the molecular landscape: integrating single-cell transcriptomics to unravel myofibroblast dynamics and therapeutic targets in clear cell renal cell carcinomas

Deciphering the molecular landscape: integrating single-cell transcriptomics to unravel myofibroblast dynamics and therapeutic targets in clear cell renal cell carcinomas

BackgroundClear cell renal cell carcinomas (ccRCCs) epitomize the most formidable clinical subtype among renal neoplasms. While the impact of tumor-associated fibroblasts on ccRCC progression is duly acknowledged, a paucity of literature exists elucidating the intricate mechanisms and signaling path...

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Detalles Bibliográficos
Autores principales: Wenqian Zhou, Zhiheng Lin, Wang Tan
Formato: Artículo
Lenguaje:English
Publicado: Frontiers Media S.A. 2024-03-01
Colección:Frontiers in Immunology
Materias:
HMGA1+ myofibroblasts
ccRCCs
ScRNA-seq
bulk RNA-seq
experiment validation
Acceso en línea:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374931/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2024.1374931/full

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