Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease

Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease

Gene-based tests to study the combined effect of rare variants on a particular phenotype have been widely developed for case-control studies, but their evolution and adaptation for family-based studies, especially studies of complex incomplete families, has been slower. In this study, we have perfor...

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Bibliographic Details
Main Authors: Maria V. Fernández, John Budde, Jorge L. Del-Aguila, Laura Ibañez, Yuetiva Deming, Oscar Harari, Joanne Norton, John C. Morris, Alison M. Goate, NIA-LOAD family study group, NCRAD, Carlos Cruchaga
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Neuroscience
Subjects:
gene-based
family-based
clustering
variance-component
transmission disequilibrium
rare variants
Online Access:http://journal.frontiersin.org/article/10.3389/fnins.2018.00209/full

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http://journal.frontiersin.org/article/10.3389/fnins.2018.00209/full

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