SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop

SOD1 Promotes Cell Proliferation and Metastasis in Non-small Cell Lung Cancer via an miR-409-3p/SOD1/SETDB1 Epigenetic Regulatory Feedforward Loop

Superoxide dismutase 1(SOD1) is a major antioxidant with oncogenic effects in many human cancers. Although SOD1 is overexpressed in various cancers, the clinical significance and functions of SOD1 in non-small cell lung cancer (NSCLC), particularly the epigenetic regulation of SOD1 in NSCLC carcinog...

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Bibliographic Details
Main Authors: Shilong Liu, Bin Li, Jianyu Xu, Songliu Hu, Ning Zhan, Hong Wang, Chunzi Gao, Jian Li, Xiangying Xu
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-04-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
non-small cell lung cancer
SOD1
miR-409-3p
SETDB1
methylation
feedforward loop
Online Access:https://www.frontiersin.org/article/10.3389/fcell.2020.00213/full

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https://www.frontiersin.org/article/10.3389/fcell.2020.00213/full

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