Impact of in vitro HIV infection on human thymic regulatory T cell differentiation

Impact of in vitro HIV infection on human thymic regulatory T cell differentiation

BackgroundThe differentiation and function of immunosuppressive regulatory T cells (Tregs) is dictated by the master transcription factor FoxP3. During HIV infection, there is an increase in Treg frequencies in the peripheral blood and lymphoid tissues. This accentuates immune dysfunction and diseas...

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Bibliographic Details
Main Authors: Sharada Swaminathan, Tatiana Scorza, Alexis Yero, Omar Farnos, Stephanie C. Burke Schinkel, Jonathan B. Angel, Mohammad-Ali Jenabian
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-07-01
Series:Frontiers in Microbiology
Subjects:
HIV
thymus
regulatory T cells
Treg
thymocytes
FoxP3
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2023.1217801/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2023.1217801/full

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