Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA

Mouse APOBEC1 cytidine deaminase can induce somatic mutations in chromosomal DNA

Abstract Background APOBEC1 (A1) enzymes are cytidine deaminases involved in RNA editing. In addition to this activity, a few A1 enzymes have been shown to be active on single stranded DNA. As two human ssDNA cytidine deaminases APOBEC3A (A3A), APOBEC3B (A3B) and related enzymes across the spectrum...

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Bibliographic Details
Main Authors: Vincent Caval, Wenjuan Jiao, Noémie Berry, Pierre Khalfi, Emmanuelle Pitré, Valérie Thiers, Jean-Pierre Vartanian, Simon Wain-Hobson, Rodolphe Suspène
Format: Article
Language:English
Published: BMC 2019-11-01
Series:BMC Genomics
Subjects:
APOBEC1
Cytidine deaminase
Somatic mutations
Nuclear DNA
Cancer
Online Access:http://link.springer.com/article/10.1186/s12864-019-6216-x

Internet

http://link.springer.com/article/10.1186/s12864-019-6216-x

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